目的 研究预知子[Akebia trifoliate (Thunb) koidz]的化学成分。方法 采用柱色谱和半制备液相色谱进行分离, 利用化合物的光谱数据结合理化性质鉴定化合物的结构。结果 分离鉴定了15个化合物,分别为京尼平苷酸(1)、10-乙酰基京尼平苷酸(2)、3-氧化-6-羟基紫罗兰醇(3)、对羟基苯甲酸(4)、原儿茶酸(5)、咖啡酸(6)、酪醇(7)、棕榈酸(8)、15-二十九烷醇(9)、豆甾醇(10)、豆甾醇-3-O-β-D-吡喃葡萄糖苷(11)、β-谷甾醇(12)、β-胡萝卜苷(13)、熊果酸(14)和齐墩果酸(15)。 结论 化合物1~7,9,14为首次从预知子中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of the fruits of Akebiae quinata. METHODS Various column chromatography techniques including silica gel, Sephadex LH-20, and macroporous adsorption resin column chromatography were used for fractionization and purification. The structures were identified on the basis of their physicochemical and spectroscopic evidence. RESULTS Fifteen compounds were obtained, and their structures were identified as geniposidic acid(1), 10-O-acetylgeniposidic acid(2), vomifoliol(3), p-hydroxybenzoic acid(4), protocatechuic acid(5), caffeic acid(6), tyrosol(7), palmitic acid(8), 15-nonacosanol(9), stigmasterol(10), stigmasterol-3-O-β-D-glycopyranoside(11), β-sitosterol(12), β-daucosterol(13), ursolic acid(14), and oleanolic acid(15). CONCLUSION Compounds 1-7, 9 and 14 were isolated from the fruits of Akebiae quinata for the first time.
关键词
预知子 /
结构鉴定 /
京尼平苷酸 /
10-乙酰基京尼平苷酸 /
3-氧化-6-羟基-紫罗兰醇
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Key words
Akebiae quinata /
structure identification /
geniposidic acid /
10-O-acetylgeniposidic acid /
vomifoliol
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中图分类号：
O629
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参考文献
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脚注
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基金
国家质检总局科技计划资助项目(2013IK291);质检公益性行业科研资助项目(201310230)
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